发给老马备查:0 \, Z( _. X2 D
滴水察海(69304838) 15:23:23
* C+ z7 O4 F9 X6 a老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
. K1 D7 Y: [9 R: c$ e* O8 @吉非替尼和S-1连用的依据" B" L( w& S% b! M K* i9 G
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
6 _4 Y3 c4 ?, Y/ p是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
0 x2 T, m7 O3 Z6 W) C1 ^这样是不是推理出,耐药后,可以用S-1和培美了?! Z+ v( z3 k+ `$ V
结论:. d* l ]1 R* u, K! N, J2 Q0 L
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |